1615219682  

上圖.皮膚重構前的毛囊  
中圖.皮膚重構訊號增加毛囊的尺寸 
下圖.周圍的皮膚在毛囊增長的同時,也製造更多新的皮膚細胞與組織 

References

Role of Sonic hedgehog signaling in epithelial and mesenchymal development of hair follicles in an organ culture of embryonic mouse, Nanba D, Nakanishi Y, Hieda Y., Dev Growth Differ. 2003 Jun;45(3):231-9

Transient activation of beta -catenin signaling in cutaneous keratinocyte is sufficient to trigger the active growth phase of the hair cycle in mice, Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER., Genes Dev. 2003 May 15;17(10):1219-24;

Hair cycle regulation of Hedgehog signal reception., Oro AE, Higgins K., Dev Biol. 2003 Mar 15;255(2):238-48,

Establishment of cadherin-based intercellular junctions in the dermal  papilla of the developing hair follicle., Nanba D, Nakanishi Y, Hieda Y., Anat Rec. 2003 Feb 1,270A(2):97-102; Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development., Mill P, Mo R, Fu H, Grachtchouk M, Kim PC, Dlugosz AA, Hui CC., Genes Dev. 2003 Jan 15;17(2):282-94;

Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia., Sato N, Leopold PL, Crystal RG., J Natl Cancer Inst. 2001 Dec 19:93(24):1858-64;

Noggin is required for induction of the hair follicle growth phase in postnatal skin., Botchkarev VA, Botchkareva NV, Nakamura M, Huber 0, Funa K, Lauster  R, Paus R Gilchrest BA., FASEB J. 2001 Oct; 15(12):2205-14;

Beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin., Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W., Cell. 2001 May 18;105(4):533-45;

Controls of hair follicle cycling, Stenn KS, Paus R, Physiol Rev. 2001 Jan:81(1):449-494; Beauty is skin deep: the fascinating biology of the epidermis and its appendages., Fuchs E., Harvey Lect. 1998-99:94:47-77)

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